Establishing a permanent and continuously growing human presence on the surface of the Earth's moon could be a pivotal point in human cultural evolution. Humans could utilize the lunar regolith to produce oxygen for breathing and as a chemical component of water. Additionally 5 to 10 meters of lunar soil could be used to shield lunar habitats from the deleterious effect of cosmic radiation.
If humans living at a lunar facility for several years can remain healthy and perhaps even reproduce under the Moon's 1/6 hypogravity environment then humanity will no longer have to confine its existence to the surface of the Earth, allowing us to expand human civilization to the Moon, Mars, and perhaps Mercury which should greatly enhance the survival of the human species in the solar system.